Kalsitonin

Kalsitonin
Struktur sedia ada
PDB	Pencarian UniProt manusia: PDBe RCSB
Senarai kod PDB
	2JXZ,%%s1LS7
Pengecam
Alias	CALCA, CT, CGRP-I, CGRP-alpha, KC, PCT, calcitonin related polypeptide alpha, CGRP, CGRP1, CALC1
Pengecam-pengecam luaran	OMIM: 114130 HomoloGene: 88401 GeneCards: CALCA
Kedudukan gen (Manusia)
Kr.	Kromosom 11
Tamat	14,972,351 bp
Corak ekspresi RNA
	Top expressed in
	Ganglion akar dorsal; ; trigeminal ganglion; ; buah pinggang; ; quadriceps femoris muscle; ; vastus lateralis muscle; ; cerebellar vermis; ; Kelenjar pankreas; ; tibialis anterior muscle; ; right lobe of liver; ; left lobe of thyroid gland;
	tiada data
	More reference expression data
	; ; ; ;
	Rujukan lanjutan untuk data ekspresi
Ontologi gen
Fungsi molekul	hormone activity; calcitonin receptor binding; Pengikatan protein plasma; identical protein binding; signaling receptor binding; protein-containing complex binding;
Komponen sel	Sitoplasma; Intrasel; extracellular region; akson; terminal bouton; neuronal cell body; neuron projection; nukleus sel; Ekstrasel;
Proses biologi	cellular response to nerve growth factor stimulus; positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway; negative regulation of smooth muscle contraction; regulation of heart contraction; monocyte chemotaxis; negative regulation of blood pressure; positive regulation of cytosolic calcium ion concentration; cellular response to tumor necrosis factor; penuaan; vasodilation; cellular calcium ion homeostasis; response to heat; negative regulation of nervous system process; positive regulation of ossification; activation of adenylate cyclase activity; regulation of heart rate; detection of temperature stimulus involved in sensory perception of pain; negative regulation of ossification; response to pain; artery vasodilation involved in baroreceptor response to increased systemic arterial blood pressure; feeding behavior; inflammatory response; neuropeptide signaling pathway; negative regulation of transcription, DNA-templated; activation of protein kinase activity; embryo implantation; negative regulation of bone resorption; regulation of signaling receptor activity; G protein-coupled receptor signaling pathway; adenylate cyclase-activating G protein-coupled receptor signaling pathway; regulation of cytosolic calcium ion concentration; leukocyte cell-cell adhesion; G protein-coupled receptor internalization; positive regulation of interleukin-1 alpha production; response to yeast; negative regulation of osteoclast differentiation; cell-cell signaling; antibacterial humoral response; positive regulation of macrophage differentiation; receptor internalization; regulation of blood pressure; protein phosphorylation; vasculature development; defense response to Gram-negative bacterium; endothelial cell proliferation; positive regulation of interleukin-8 production; nervous system process involved in regulation of systemic arterial blood pressure; negative regulation of calcium ion transport into cytosol; Sistem imun semula jadi; endothelial cell migration; antifungal humoral response; defense response to Gram-positive bacterium; antimicrobial humoral immune response mediated by antimicrobial peptide; amylin receptor signaling pathway; calcitonin gene-related peptide receptor signaling pathway;
	Sumber:Amigo / QuickGO
Ortolog
	796
	tiadadata
	ENSG00000110680
	tiadadata
	P06881
	tiada data
	NM_001033952; NM_001033953; NM_001741; NM_001378949; NM_001378950
	tiada data
	NP_001029125.1
	tiada data
	Wikidata
Papar/Sunting data manusia

Kalsitonin (juga dikenali sebagai tirokalsitonin) ialah suatu hormon polipeptida linear asid asid 32-amino yang dihasilkan di dalam manusia terutamanya oleh sel parafolikel (juga dikenali sebagai sel C) bagi tiroid, dan pada banyak lagi haiwan di dalam jasad ultimobrankium.^[4] Hormon ini bertindak untuk mengurangkan kalsium darah (Ca²⁺), bertentangan dengan kesan hormon paratiroid (PTH).^[5] Kalsitonin telah dijumpai pada ikan, reptilia, burung, dan mamalia. Kepentingannya pada manusia belum diasaskan dengan baik seperti kepentingannya pada haiwan lain, kerana fungsinya biasanya tidak ketara dalam pengawalaturan homeostasis kalsium normal.^[6] Hormon ini tergolong dalam keluarga protein seperti kalsitonin.

Lihat juga sunting

Prokalsitonin

Rujukan sunting

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000110680 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Costoff A. "Sect. 5, Ch. 6: Anatomy, Structure, and Synthesis of Calcitonin (CT)". Endocrinology: hormonal control of calcium and phosphate. Kolej Perubatan Georgia. Dicapai pada 7 Ogos 2008. Cite has empty unknown parameter: |coauthors= (bantuan)
^ Boron WF, Boulpaep EL (2004). "Endocrine system chapter". Medical Physiology: A Cellular And Molecular Approach. Elsevier/Saunders. ISBN 1-4160-2328-3.
^ Costoff A. "Sect. 5, Ch. 6: Biological Actions of CT". Kolej Perubatan Georgia. Diarkibkan daripada yang asal pada 2008-07-05. Dicapai pada 7 Ogos 2008. Cite has empty unknown parameter: |coauthors= (bantuan)

Bacaan lanjut sunting

MacIntyre I, Alevizaki M, Bevis PJ, Zaidi M (1987). "Calcitonin and the peptides from the calcitonin gene". Clin. Orthop. Relat. Res. &na, (217): 45–55. doi:10.1097/00003086-198704000-00007. PMID 3549095.CS1 maint: extra punctuation (link) CS1 maint: multiple names: authors list (link)
Di Angelantonio S, Giniatullin R, Costa V; dll. (2004). "Modulation of neuronal nicotinic receptor function by the neuropeptides CGRP and substance P on autonomic nerve cells". Br. J. Pharmacol. 139 (6): 1061–73. doi:10.1038/sj.bjp.0705337. PMC 1573932. PMID 12871824. Explicit use of et al. in: |author= (bantuan)CS1 maint: multiple names: authors list (link)
Findlay DM, Sexton PM (2005). "Calcitonin". Growth Factors. 22 (4): 217–24. doi:10.1080/08977190410001728033. PMID 15621724.
Sponholz C, Sakr Y, Reinhart K, Brunkhorst F (2007). "Diagnostic value and prognostic implications of serum procalcitonin after cardiac surgery: a systematic review of the literature". Critical care (London, England). 10 (5): R145. doi:10.1186/cc5067. PMC 1751067. PMID 17038199.CS1 maint: multiple names: authors list (link)
Schneider HG, Lam QT (2007). "Procalcitonin for the clinical laboratory: a review". Pathology. 39 (4): 383–90. doi:10.1080/00313020701444564. PMID 17676478.

Pautan luar sunting

The Calcitonin Protein
Calcitonin dalam Tajuk Subjek Perubatan (MeSH) di Perpustakaan Perubatan Negara AS

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000110680 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Costoff_Calcitonin_Structure-4] Costoff A. "Sect. 5, Ch. 6: Anatomy, Structure, and Synthesis of Calcitonin (CT)". Endocrinology: hormonal control of calcium and phosphate. Kolej Perubatan Georgia. Dicapai pada 7 Ogos 2008. Cite has empty unknown parameter: |coauthors= (bantuan)

[isbn1-4160-2328-3-5] Boron WF, Boulpaep EL (2004). "Endocrine system chapter". Medical Physiology: A Cellular And Molecular Approach. Elsevier/Saunders. ISBN 1-4160-2328-3.

[Costoff_Calcitonin_Biological_Actions-6] Costoff A. "Sect. 5, Ch. 6: Biological Actions of CT". Kolej Perubatan Georgia. Diarkibkan daripada yang asal pada 2008-07-05. Dicapai pada 7 Ogos 2008. Cite has empty unknown parameter: |coauthors= (bantuan)

[4]

[5]

[6]

[1]

[2]

[3]