Phillip Allen Sharp
Phillip Allen Sharp (dilahirkan pada 6 Jun 1944) ialah ahli biologi dan ahli biologi molekul Amerika yang bersama-sama menemui penjalinan RNA. Beliau berkongsi Hadiah Nobel dalam Fisiologi atau Perubatan 1993 bersama Richard J. Roberts untuk "penemuan bahawa gen dalam eukariota bukan rentetan bersambung tetapi mengandungi intron, dan utusan penjalinan RNA untuk memadam intron tersebut boleh terjadi dengan cara yang berbeza, menghasilkan yang berbeza protein dari urutan DNA yang sama".[1][2][3][4][5][6] Beliau telah dipilih untuk menerima Pingat Emas Othmer 2015.[7]
Penerbitan terpilih sunting
- Petersen C.P.; Bordeleau M.E.; Pelletier J.; Sharp P.A. (17 February 2006). "Short RNAs Repress Translation after Initiation in Mammalian Cells". Mol Cell. 21 (4): 533–42. doi:10.1016/j.molcel.2006.01.031. PMID 16483934.
- Cheng C.; Sharp P.A. (January 2006). "Regulation of CD44 Alternative Splicing by SRm160 and its Potential Role in Tumor Cell Invasion". Mol Cell Biol. 26 (1): 362–70. doi:10.1128/MCB.26.1.362-370.2006. PMC 1317625. PMID 16354706.
- Tantin D.; Schild-Poulter C.; Wang V.; Hache R.J.; Sharp P.A. (1 December 2005). "The Octamer Binding Transcription Factor Oct-1 is a Stress Sensor". Cancer Res. 65 (23): 10750–8. doi:10.1158/0008-5472.CAN-05-2399. PMID 16322220.
- Grishok A.; Sharp P.A. (29 November 2005). "Negative Regulation of Nuclear Divisions in Caenorhabditis Elegans by Retinoblastoma and RNA Interference-related Genes". Proc Natl Acad Sci U S A. 102 (48): 17360–5. doi:10.1073/pnas.0508989102. PMC 1297700. PMID 16287966.
- Sharp P.A. (7 October 2005). "1918 Flu and Responsible Science". Science. 310 (5745): 17. doi:10.1126/science.310.5745.17. PMID 16210500.
- Miskevich F.; Doench J.G.; Townsend M.T.; Sharp P.A.; Constantine-Paton M. (15 April 2006). "RNA Interference of Xenopus NMDAR NR1 in vitro and in vivo". J Neurosci Methods. 152 (1–2): 65–73. doi:10.1016/j.jneumeth.2005.08.010. PMID 16182372.
- Hong J.H.; Hwang E.S.; McManus M.T.; Amsterdam A.; Tian Y.; Kalmukova R.; Mueller E.; Benjamin T.; Spiegelman B.M. (12 August 2005). "TAZ, a Transcriptional Modulator of Mesenchymal Stem Cell Differentiation". Science. 309 (5737): 1074–8. doi:10.1126/science.1110955. PMID 16099986.
- Houbaviy H.B.; Dennis L.; Jaenisch R.; Sharp P.A. (August 2005). "Characterization of a Highly Variable Eutherian microRNA Gene". RNA. 11 (8): 1245–57. doi:10.1261/rna.2890305. PMC 1370808. PMID 15987809.
- Sharp P.A. (June 2005). "The Discovery of Split Genes and RNA Splicing". Trends Biochem. Sci. 30 (6): 279–81. doi:10.1016/j.tibs.2005.04.002. PMID 15950867.
- Johnson D.M.; Yamaji S.; Tennant J.; Srai S.K.; Sharp P.A. (28 March 2005). "Regulation of Divalent Metal Transporter Expression in Human Intestinal Epithelial Cells Following Exposure to Non-haem Iron". FEBS Lett. 579 (9): 1923–9. doi:10.1016/j.febslet.2005.02.035. PMID 15792797.
- Neilson J.R.; Sharp P.A. (April 2005). "Herpesviruses Throw a Curve Ball: New Insights into microRNA Biogenesis and Evolution". Nat Methods. 2 (4): 252–4. doi:10.1038/nmeth0405-252. PMID 15782215.
- Grishok A.; Sinskey J.L.; Sharp P.A. (15 March 2005). "Transcriptional Silencing of a Transgene by RNAi in the Soma of C. elegans". Genes Dev. 19 (6): 683–96. doi:10.1101/gad.1247705. PMC 1065722. PMID 15741313.
- Sharp P.A.; Sharp, P (1 January 2005). "Phillip Sharp Discusses RNAi, Nobel Prizes and Entrepreneurial Science". Drug Discov Today. 10 (1): 7–10. doi:10.1016/S1359-6446(04)03329-X. PMID 15676292.
- Lee K.B.; Sharp P.A. (7 December 2004). "Transcription-dependent Polyubiquitination of RNA Polymerase II Requires Lysine 63 of Ubiquitin". Biochemistry. 43 (48): 15223–9. doi:10.1021/bi048719x. PMID 15568815.
- Mansfield J.H.; Harfe B.D.; Nissen R.; Obenauer J.; Srineel J.; Chaudhuri A.; Farzan-Kashani R.; Zuker M.; Pasquinelli A.E. (October 2004). "MicroRNA-responsive 'Sensor' Transgenes Uncover Hox-like and Other Developmentally Regulated Patterns of Vertebrate MicroRNA Expression". Nat. Genet. 36 (10): 1079–83. doi:10.1038/ng1421. PMID 15361871.
- Fairbrother W.G.; Holste D.; Burge C.B.; Sharp P.A. (September 2004). "Single Nucleotide Polymorphism-based Validation of Exonic Splicing Enhancers". PLoS Biol. 2 (9): E268. doi:10.1371/journal.pbio.0020268. PMC 514884. PMID 15340491.
- Novina C.D.; Sharp P.A. (July 8, 2004). "The RNAi Revolution". Nature. 430 (6996): 161–4. doi:10.1038/430161a. PMID 15241403.
- Ventura A.; Meissner A.; Dillon C.P.; McManus M.; Sharp P.A.; Van Parijs L.; Jaenisch R.; Jacks T. (July 13, 2004). "Cre-lox-regulated Conditional RNA Interference from Transgenes". Proc Natl Acad Sci U S A. 101 (28): 10380–5. doi:10.1073/pnas.0403954101. PMC 478580. PMID 15240889.
Rujukan sunting
- ^ "The Nobel Prize in Physiology or Medicine 1993". Nobelprize.org. Nobel Media. Dicapai pada 12 November 2014.
- ^ Sharp, P (2011). "Q&A: Phillip Sharp on biomedical convergence". Cancer Discovery. 1 (5): 370. doi:10.1158/2159-8290.CD-ND11-08. PMID 22586619.
- ^ Musgrave, E (2010). "Advancing science across the disciplines: An interview with Nobel Laureate Phillip A. Sharp, PhD". Clinical and Translational Science. 3 (3): 69–70. doi:10.1111/j.1752-8062.2010.00197.x. PMC 5350715. PMID 20590673.
- ^ Sharp, P. A.; Sharp, P (2005). "Phillip Sharp discusses RNAi, Nobel Prizes and entrepreneurial science". Drug Discovery Today. 10 (1): 7–10. doi:10.1016/S1359-6446(04)03329-X. PMID 15676292.
- ^ Shampo, M. A.; Kyle, R. A. (2004). "Phillip Sharp--Nobel Prize for discovery of "split genes"". Mayo Clinic Proceedings. 79 (6): 727. doi:10.1016/s0025-6196(11)62621-9. PMID 15182083.
- ^ Raju, T. N. (2000). "The Nobel chronicles. 1993: Richard John Roberts (b 1943) Phillip a Sharp (b 1944)". Lancet. 355 (9220): 2085. doi:10.1016/s0140-6736(05)73547-9. PMID 10885388.
- ^ "Othmer Gold Medal". Science History Institute. Dicapai pada 4 February 2015.