Metaloprotein

Metaloprotein ialah sebuah istilah bagi protein dengan kofaktor ion logam.^[1]^[2] Banyakprotein yang diketahui tergolonng dalam kumpulan ini. Sebagai contoh, sekurang-kurangnya 1000 protein manusia (daripada sekitar 20,000) domain protein dengan ikatan atom zink^[3] walaupun diduga mungkin ada sehingga 3000 metaloprotein zink dalam manusia.^[4]

Limpahan sunting

Anggaran menduga bahaw kira-kira separuh daripada semua protein yang wujud memiliki logam.^[5] Dalam satu lagi anggaran, sekitar suku hingga sepertiga protein yang wujud memerlukan logam untuk menjalankan fungsinya.^[6] Oleh itu, metaloprotein memiliki banyak fungsi dalam sel seperti penyimpanan dan pengangkutan protein.^[7] Limpahan metaloprotein ini mungkin telah diwarisi daripada asid amino yang membentuk protein memandangkan protein buatan juga ditemui bersedia berikat dengan atom-atom logam.^[8]

Rujukan sunting

^ Banci L (2013). Sigel A, Sigel H, Sigel RK (penyunting). Metallomics and the Cell. Metal Ions in Life Sciences. 12. Springer. m/s. 1–13. doi:10.1007/978-94-007-5561-1_1. ISBN 978-94-007-5561-1. PMID 23595668.
^ Shriver DF, Atkins PW (1999). "Charper 19, Bioinorganic chemistry". Inorganic chemistry (ed. 3rd). Oxford University Press. ISBN 978-0-19-850330-9.
^ Human reference proteome in Uniprot, accessed 12 Jan 2018
^ Andreini C, Banci L, Bertini I, Rosato A (November 2006). "Zinc through the three domains of life". Journal of Proteome Research. 5 (11): 3173–8. doi:10.1021/pr0603699. PMID 17081069.
^ Thomson AJ, Gray HB (1998). "Bioinorganic chemistry" (PDF). Current Opinion in Chemical Biology. 2 (2): 155–158. doi:10.1016/S1367-5931(98)80056-2. PMID 9667942.
^ Waldron KJ, Robinson NJ (January 2009). "How do bacterial cells ensure that metalloproteins get the correct metal?". Nature Reviews. Microbiology. 7 (1): 25–35. doi:10.1038/nrmicro2057. PMID 19079350. S2CID 7253420.
^ Carver PL (2013). "Chapter 1. Metal Ions and Infectious Diseases. An Overview from the Clinic". Dalam Sigel A, Sigel H, Sigel RK (penyunting). Interrelations between Essential Metal Ions and Human Diseases. Metal Ions in Life Sciences. 13. Springer. m/s. 1–28. doi:10.1007/978-94-007-7500-8_1. ISBN 978-94-007-7499-5. PMID 24470087.
^ Wang, MS; Hoegler, KH; Hecht, M (2019). "Unevolved De Novo Proteins Have Innate Tendencies to Bind Transition Metals". Life. 9 (8): 8. doi:10.3390/life9010008. PMC 6463171. PMID 30634485.

Pautan luar sunting

Metalloprotein dalam Tajuk Subjek Perubatan (MeSH) di Perpustakaan Perubatan Negara AS

[1] Banci L (2013). Sigel A, Sigel H, Sigel RK (penyunting). Metallomics and the Cell. Metal Ions in Life Sciences. 12. Springer. m/s. 1–13. doi:10.1007/978-94-007-5561-1_1. ISBN 978-94-007-5561-1. PMID 23595668.

[AS-2] Shriver DF, Atkins PW (1999). "Charper 19, Bioinorganic chemistry". Inorganic chemistry (ed. 3rd). Oxford University Press. ISBN 978-0-19-850330-9.

[3] Human reference proteome in Uniprot, accessed 12 Jan 2018

[4] Andreini C, Banci L, Bertini I, Rosato A (November 2006). "Zinc through the three domains of life". Journal of Proteome Research. 5 (11): 3173–8. doi:10.1021/pr0603699. PMID 17081069.

[5] Thomson AJ, Gray HB (1998). "Bioinorganic chemistry" (PDF). Current Opinion in Chemical Biology. 2 (2): 155–158. doi:10.1016/S1367-5931(98)80056-2. PMID 9667942.

[6] Waldron KJ, Robinson NJ (January 2009). "How do bacterial cells ensure that metalloproteins get the correct metal?". Nature Reviews. Microbiology. 7 (1): 25–35. doi:10.1038/nrmicro2057. PMID 19079350. S2CID 7253420.

[7] Carver PL (2013). "Chapter 1. Metal Ions and Infectious Diseases. An Overview from the Clinic". Dalam Sigel A, Sigel H, Sigel RK (penyunting). Interrelations between Essential Metal Ions and Human Diseases. Metal Ions in Life Sciences. 13. Springer. m/s. 1–28. doi:10.1007/978-94-007-7500-8_1. ISBN 978-94-007-7499-5. PMID 24470087.

[Wang2019-8] Wang, MS; Hoegler, KH; Hecht, M (2019). "Unevolved De Novo Proteins Have Innate Tendencies to Bind Transition Metals". Life. 9 (8): 8. doi:10.3390/life9010008. PMC 6463171. PMID 30634485.

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