Yoshinori Ohsumi

Yoshinori Ohsumi (Jepun: 大隅 良典, Hepburn: Ōsumi Yoshinori) (lahir 9 Februari 1945) ialah ahli biologi sel jepun yang pakar dalam autofagi, proses yang digunakan sel untuk memusnahkan dan mengitar semula komponen selular. Ohsumi ialah profesor di Institut Penyelidikan Inovatif Institut Teknologi Tokyo. Beliau menerima Hadiah Kyoto untuk Sains Asas pada tahun 2012, Hadiah Nobel dalam Fisiologi atau Perubatan pada tahun 2016, dan Hadiah Terobosan 2017 dalam Sains Hayat bagi penemuan mekanisme autofaginya.

Yoshinori Ohsumi

Penerbitan terpilih

His original findings about autophagy in yeast cells:

• Ohsumi, Yoshinori (October 1992). "Autophagy in Yeast Demonstrated with Proteinase-Deficient Mutants and Conditions for Its Induction". The Journal of Cell Biology. 119 (2): 301–311. doi:10.1083/jcb.119.2.301. JSTOR 1615399. PMC 2289660. PMID 1400575.

Follow up with more research on yeast:

• Ohsumi, Yoshinori (March 1994). "Ultrastructural Analysis of the Autophagic Process in Yeast: Detection of Autophagosomes and Their Characterization". The Journal of Cell Biology. 124 (6): 903–913. doi:10.1083/jcb.124.6.903. JSTOR 1616094. PMC 2119983. PMID 8132712.

Others

• Tsukada, M; Ohsumi, Y (25 October 1993). "Isolation and characterization of autophagy-defective mutants of Saccharomyces cerevisiae". FEBS Letters. 333 (1–2): 169–74. doi:10.1016/0014-5793(93)80398-e. PMID 8224160.
• Mizushima, N; Noda, T; Yoshimori, T; Tanaka, Y; Ishii, T; George, MD; Klionsky, DJ; Ohsumi, M; Ohsumi, Y (24 September 1998). "A protein conjugation system essential for autophagy". Nature. 395 (6700): 395–8. Bibcode:1998Natur.395..395M. doi:10.1038/26506. PMID 9759731.
• Kabeya, Y; Mizushima, N; Ueno, T; Yamamoto, A; Kirisako, T; Noda, T; Kominami, E; Ohsumi, Y; Yoshimori, T (2000). "LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing". The EMBO Journal. 19 (21): 5720–5728. doi:10.1093/emboj/19.21.5720. PMC 305793. PMID 11060023.
• Ichimura, Y; Kirisako, T; Takao, T; Satomi, Y; Shimonishi, Y; Ishihara, N; Mizushima, N; Tanida, I; Kominami, E (23 November 2000). "A ubiquitin-like system mediates protein lipidation". Nature. 408 (6811): 488–92. Bibcode:2000Natur.408..488I. doi:10.1038/35044114. PMID 11100732.
• Ohsumi, Y (March 2001). "Molecular dissection of autophagy: two ubiquitin-like systems". Nature Reviews Molecular Cell Biology. 2 (3): 211–6. doi:10.1038/35056522. PMID 11265251.
• Kuma, A; Hatano, M; Matsui, M; Yamamoto, A; Nakaya, H; Yoshimori, T; Ohsumi, Y; Tokuhisa, T; Mizushima, N (23 December 2004). "The role of autophagy during the early neonatal starvation period". Nature. 432 (7020): 1032–6. Bibcode:2004Natur.432.1032K. doi:10.1038/nature03029. PMID 15525940.
• Suzuki, Sho; Onodera, Jun; Ohsumi, Yoshinori (25 February 2011). "Starvation Induced Cell Death in Autophagy-Defective Yeast Mutants Is Caused by Mitochondria Dysfunction". PLOS ONE. 6 (2): e17412. doi:10.1371/journal.pone.0017412. PMC 3045454. PMID 21364763.
• Hanada, T; Noda, NN; Satomi, Y; Ichimura, Y; Fujioka, Y; Takao, T; Inagaki, F; Ohsumi, Y (28 December 2007). "The Atg12-Atg5 conjugate has a novel E3-like activity for protein lipidation in autophagy". The Journal of Biological Chemistry. 282 (52): 37298–302. doi:10.1074/jbc.c700195200. PMID 17986448.
• Ohsumi, Yoshinori (December 2013). "Highly Oxidized Peroxisomes Are Selectively Degraded via Autophagy in Arabidopsis". The Plant Cell. 25 (12): 4967–4983. doi:10.1105/tpc.113.116947. JSTOR 43190612. PMC 3903999. PMID 24368788.
• Yamamoto, H; Ohsumi, Y (October 6, 2015). "The Thermotolerant Yeast Kluyveromyces marxianus Is a Useful Organism for Structural and Biochemical Studies of Autophagy". The Journal of Biological Chemistry. 290 (49): 29506–29518. doi:10.1074/jbc.M115.684233. PMC 4705951. PMID 26442587.
• Yamamoto, H; Ohsumi, Y (11 July 2016). "The intrinsically disordered protein Atg13 mediates supramolecular assembly of autophagy initiation complexes". Dev. Cell. 38 (1): 86–99. doi:10.1016/j.devcel.2016.06.015. PMID 27404361.