Subunit hemoglobin alfa

Subunit hemoglobin alfa
Struktur sedia ada
PDB	Pencarian ortolog: PDBe RCSB
Senarai kod PDB
	1A00, 1A01, 1A0U, 1A0Z, 1A3N, 1A3O, 1A9W, 1ABW, 1ABY, 1AJ9, 1B86, 1BAB, 1BBB, 1BIJ, 1BUW, 1BZ0, 1BZ1, 1BZZ, 1C7B, 1C7C, 1C7D, 1CLS, 1CMY, 1COH, 1DKE, 1DXT, 1DXU, 1DXV, 1FDH, 1FN3, 1G9V, 1GBU, 1GBV, 1GLI, 1GZX, 1HAB, 1HAC, 1HBA, 1HBB, 1HBS, 1HCO, 1HDB, 1HGA, 1HGB, 1HGC, 1HHO, 1IRD, 1J3Y, 1J3Z, 1J40, 1J41, 1J7S, 1J7W, 1J7Y, 1JY7, 1K0Y, 1K1K, 1KD2, 1LFL, 1LFQ, 1LFT, 1LFV, 1LFY, 1LFZ, 1LJW, 1M9P, 1MKO, 1NEJ, 1NIH, 1NQP, 1O1I, 1O1J, 1O1K, 1O1L, 1O1M, 1O1N, 1O1O, 1O1P, 1QI8, 1QSH, 1QSI, 1QXD, 1QXE, 1R1X, 1R1Y, 1RPS, 1RQ3, 1RQ4, 1RQA, 1RVW, 1SDK, 1SDL, 1SHR, 1SI4, 1THB, 1UIW, 1VWT, 1XXT, 1XY0, 1XYE, 1XZ2, 1XZ4, 1XZ5, 1XZ7, 1XZU, 1XZV, 1Y01, 1Y09, 1Y0A, 1Y0C, 1Y0D, 1Y0T, 1Y0W, 1Y22, 1Y2Z, 1Y31, 1Y35, 1Y45, 1Y46, 1Y4B, 1Y4F, 1Y4G, 1Y4P, 1Y4Q, 1Y4R, 1Y4V, 1Y5F, 1Y5J, 1Y5K, 1Y7C, 1Y7D, 1Y7G, 1Y7Z, 1Y83, 1Y85, 1Y8W, 1YDZ, 1YE0, 1YE1, 1YE2, 1YEN, 1YEO, 1YEQ, 1YEU, 1YEV, 1YFF, 1YG5, 1YGD, 1YGF, 1YH9, 1YHE, 1YHR, 1YIE, 1YIH, 1YVQ, 1YVT, 1YZI, 1Z8U, 2D5Z, 2D60, 2DN1, 2DN2, 2DN3, 2DXM, 2H35, 2HBC, 2HBD, 2HBE, 2HBF, 2HBS, 2HCO, 2HHD, 2HHE, 2M6Z, 2W6V, 2W72, 2YRS, 3B75, 3D17, 3D7O, 3DUT, 3HXN, 3IA3, 3IC0, 3IC2, 3KMF, 3NL7, 3NMM, 3ODQ, 3ONZ, 3OO4, 3OO5, 3OVU, 3P5Q, 3QJB, 3QJC, 3QJD, 3QJE, 3R5I, 3S48, 3S65, 3S66, 3SZK, 3WCP, 3WHM, 4FC3, 4HHB, 4IJ2, 4L7Y, 4M4A, 4M4B, 4MQC, 4MQG, 4MQH, 4MQI, 4MQJ, 4MQK, 4N7N, 4N7O, 4N7P, 4N8T, 4NI0, 4NI1, 4ROL, 4ROM, 4WJG, 4X0L, 4XS0, 6HBW, 5E29, 5E6E, 5EE4, 5HU6, 5JDO, 5KDQ, 5E83,%%s1Y01, 1Z8U, 1BZ1
Pengecam
Alias	HBA1, HBA-T3, HBH, hemoglobin subunit alpha 1, METHBA, ECYT7
Pengecam-pengecam luaran	OMIM: 141800 MGI: 96015 HomoloGene: 469 GeneCards: HBA1
Kedudukan gen (Manusia)
Kr.	Kromosom 16
Tamat	177,522 bp
Corak ekspresi RNA
	Top expressed in
	monocyte; ; darah; ; Sumsum tulang; ; bone marrow cells; ; Plasenta; ; limpa; ; ganglionic eminence; ; temporal lobe; ; amygdala; ; upper lobe of left lung;
	Top expressed in
	Sumsum tulang; ; limpa; ; paru-paru; ; Kantung yolka; ; neural tube; ; Otak tengah; ; jantung; ; korteks serebelum; ; kawasan kulit; ; kelenjar adrenal;
	More reference expression data
	tiada data
Ontologi gen
Fungsi molekul	iron ion binding; oxygen binding; peroxidase activity; oxygen carrier activity; ikatan ion logam; Pengikatan protein plasma; heme binding; haptoglobin binding; organic acid binding;
Komponen sel	cytosol; endocytic vesicle lumen; blood microparticle; membran; extracellular region; cytosolic small ribosomal subunit; hemoglobin complex; extracellular exosome; haptoglobin-hemoglobin complex; Ekstrasel;
Proses biologi	positive regulation of cell death; protein heterooligomerization; oxygen transport; receptor-mediated endocytosis; bicarbonate transport; hydrogen peroxide catabolic process; response to hydrogen peroxide; cellular oxidant detoxification; transport;
	Sumber:Amigo / QuickGO
Ortolog
	3039
	15122
	ENSG00000206172
	ENSMUSG00000069919
	P69905
	Q91VB8
	NM_000558
	NM_008218
	NP_000508; NP_000508.1; NP_000549.1
	NP_001077424
	Wikidata
Papar/Sunting data manusia	Papar/Sunting data mencit

Subunit hemoglobin alfa^[4] ialah sebuah protein hemoglobin yang dikodkan oleh gen HBA1 dalam manusia.^[5]

Gen sunting

Kelompok gen globin alfa manusia yang terletak pada kromosom 16 menjangkau kira-kira 30 kb dan merangkumi tujuh lokus: 5'- zeta - pseudozeta - mu - pseudoalfa-1 - alfa-2 - alfa-1 - teta - 3'. Urutan pengekodan alpha-2 (HBA2) dan alpha-1 (HBA1; gen ini) adalah sama. Gen ini berbeza sedikit di wilayah 5' tidak ditranslasikan dan intron, tetapi ia berbeza ketara di wilayah 3' tidak ditranslasikan.^[5]

Protein sunting

Dua rantai alfa dengan dua rantai beta membentuk HbA yang merangkumi kira-kira 97% jumlah hemoglobin dalam kehidupan dewasa normal; rantai alfa bergabung dengan rantai delta untuk membentuk HbA-2 yang membentuk baki 3% hemoglobin dewasa bersama dengan hemoglobin janin (HbF).

Kepentingan klinikal sunting

Talasemia alfa terhasil daripada pemadaman setiap gen alfa serta pemadaman kedua-dua HBA2 dan HBA1; beberapa talasemia alfa bukan pemadaman juga telah dilaporkan.^[5]

Interaktsi sunting

Subunit hemoglobin alfa telah diperhatikan berinteraksi dengan subunit hemoglobin beta (HBB).^[6]^[7]

Rujukan sunting

Subunit hemoglobin beta

Rujukan sunting

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000206172 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "HBA1 gene: MedlinePlus Genetics".
^ ^a ^b ^c "Entrez Gene: HBA1 hemoglobin, alpha 1".
^ Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (September 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.
^ Shaanan B (November 1983). "Structure of human oxyhaemoglobin at 2.1 A resolution". J. Mol. Biol. 171 (1): 31–59. doi:10.1016/S0022-2836(83)80313-1. PMID 6644819.

Pautan luar sunting

Entri talasemia alfa di GeneReviews/NCBI/NIH/UW
Entri talasemia alfa di OMIM
Gambaran maklumat struktur tersedia di PDB bagi UniProt: P69905 (Hemoglobin subunit alpha) di PDBe-KB.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000206172 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "HBA1 gene: MedlinePlus Genetics".

[entrez-5] "Entrez Gene: HBA1 hemoglobin, alpha 1".

[pmid16169070-6] Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (September 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.

[pmid6644819-7] Shaanan B (November 1983). "Structure of human oxyhaemoglobin at 2.1 A resolution". J. Mol. Biol. 171 (1): 31–59. doi:10.1016/S0022-2836(83)80313-1. PMID 6644819.

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